Clinical and Histopathological Correlation in a Group of Patients with Oral Submucous Fibrosis- A Prospective Study

Abstract

Aim: Clinical and histopathological correlation in a group of patients with oral submucous fibrosis. Materials and Methods: Total of 45 OSMF patients clinical and histopathological staging was noted based on criteria given by Chandramani More et al & Pindborg and Sirsat (1966). The correlation between clinical staging and histopathological grading analyzed statistically using Spearman’s correlation coefficient & chi-square test. Results: We found a statistically significant positive correlation between clinical staging and histopathological grading in OSMF patients. 14 cases clinically diagnosed as stage S2M2 (31.1%) had histopathological grading early OSMF. 15 cases clinically diagnosed as stage S2M3 (33.3%) had histopathological grading moderately advanced OSMF. 9 cases clinically diagnosed as stage S3M3 (20%) also had histopathological grading moderately advanced OSMF. 7 patients clinically diagnosed as stage S3M4 (15.6%) had histopathological grading advanced OSMF. There was progressive limitation in mouth opening as the stages and grades advanced. Conclusion: There is statistically significant positive correlation between clinical staging and histopathological grading of OSMF.