Review on Formulation of Tramadol Hydrochloride Using Albumin Microsphere

Abstract

Microspheres are small spherical particles with dimensions ranging from 1 to 1000 micrometers. Microspheres are also known as micro particles. Microspheres are homogeneous, monolithic particles that improve treatment by allowing the medicine to be localized at the site of action and extending the drug's release time. According to the findings, the manufactured microspheres containing tramadol (TH) only showed small variations in particle size throughout the stability investigation, with no discernible changes in drug content, indicating that the product was stable in an accelerated environment. Microsphere’s efficacy in delaying medication release has been demonstrated in a prior study. As a result, the frequency of dose may be reduced, and patient compliance may be improved in tramadol. Tramadol is a centrally acting analgesic with a multimode of action. It acts on serotonergic and noradrenergic nociception, while its metabolite O-desmethyltramadol acts on the µ-opioid receptor.