Pulsatile Drug Delivery System – A Review

Abstract

Pulsatile drug delivery systems are gaining popularity in modern pharmaceuticals as a means of developing medications for which standard continuous-release therapies are ineffective. In some circumstances, where maintaining a steady blood level of medications is undesirable, a pulsatile drug delivery device is recommended. After a lag time, they are built in such a way that complete and quick drug release is achieved. Site-specific pulsatile drug delivery devices release the medicine at a specified location inside the digestive tract. The delivery system, rather than the external environment, controls medication release in time-controlled release. Site-controlled release refers to medication release that is regulated by pH or enzymes found in the gastrointestinal system. This study looks at several pulsatile systems, such as capsular systems, osmotic systems, single and multiple systems based on soluble and erodible polymer coatings, and the existing PDDS on the market.