An Overview of Oral Sustained-Release Tablets, with a Focus on the Matrix Tablet

Abstract

The pharmaceutical industry is currently concentrating on developing oral dosage forms with a prolonged release, which has become a crucial tool in medicine. These formulations for sustained release are intended to release medication at a predetermined rate while maintaining plasma medication levels concentration with little negative effects during the therapeutic window. The main goal of sustained-release medication administration is to modify the drug's biopharmaceutical, pharmacokinetic, and pharmacodynamic properties to lessen adverse effects, improve patient compliance, and ultimately treat the illness. Due to less frequent drug administration, less steady-state drug level fluctuations, maximum drug utilization, the enhanced safety margin of powerful drugs, lower healthcare costs due to better therapy, and shorter treatment times, sustained release drug delivery improves patient compliance. The improvement of medication therapy is the primary objective of sustained release forms, which is determined by the relationship between the benefits and drawbacks of using a sustained release system. Basic information on the matrix-type sustained-release drug delivery system was provided in this review paper.