Transdermal Drug Delivery of Nitroglycerin Using Eucalyptus Oil in Management of Angina Pectoris

Abstract

Objective: The goal of the current study was to create a transdermal patch containing Nitroglycerin and Eucalyptus Oil for the treatment of Angina Pectoris. These studies revealed a synergistic vasodilator effect between the medication and eucalyptus oil. Methods: Using HPMC K4M and ethyl cellulose as hydrophilic and hydrophobic polymers with eucalyptus oil in various ratios, Transdermal Patches containing Nitroglycerin were produced. The thickness, folding durability, weight uniformity, content uniformity, swelling index, % moisture content, moisture absorption, surface pH, and in vitro release experiments were just a few of the assessment criteria that were used to all of the patches. Results: Transdermal patch formulation TD3 demonstrated prolonged drug release (89% for 24 hours) in in vitro release experiments.