Comparative Analysis of the Anti-Epileptic Activity of Annona Muricata and Artocarpus Heterophyllus on MES Induced Seizures in Wistar Rats

Abstract

The main objective of our assessment is the comparative study of the Anti Epileptic activity of Annona muricata and Artocarpus heterophyllus on MES induced seizures in Wistar Rats. Anticonvulsants (also known as antiepileptic drugs or recently as anti-seizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Phenytoin is best standard drug for epileptic patients its belongs to Hydantoin derivatives. It works by decreasing abnormal electrical activity in the brain. Phenytoin is used to control seizures (convulsion), including tonic-clonic (grand mal) and psychomotor seizures, in the treatment of Epilepsy. The Hydro-alcoholic extracts of “Annona muricata and Artocarpus heterophyllus” were subjected to phytochemical analysis find out the presence and absence of phytochemical constituents. The phytochemical tests employed for “Annona muricata and Artocarpus were subjected to phytochemical analysis find out the presence and absence of Alkaloids, Protein, carbohydrates, flavonoids, other compounds found are tannins, saponins, terpenoids, glycosides. Results of the Present study show that the comparing Hydroalcoholic extract of Annona muricata and Artocarpus heterophyllus, Annona muricata leaves (400mg/kg) produced significant anticonvulsant effect against MES induced seizure in Rat.