Assessment on Nephroprotective Activity of Cassia Auriculata Linn on Gentamicin Induced Renal Toxicities in Albino Rats

Abstract

The main objective of our research study is to evaluate nephroprotective potentials of cassia auriculata Linn leaf extract against nephrotoxicity. Nephroprotective activity of Cassia auriculata Linn (100 mg/kg P.O) + (80mg/kg/day) I.P of gentamicin for 9 days. In this study the standard drug cystone (2ml/kg) and test drug Cassia auriculata Linn (100 mg/kg P.O) will be continued to 19th days. After 19th day of last dose animals will be sacrificed under euthanasia and kidney will be removed for histopathological evaluation. The tissue was fixed saline dehydrated with 100% of ethanol solution and embedded in paraffin. It was then processed into 4-5m thick section stained with hematoxylin-eosin and observed under a photomicroscope (magnification power-40X). All the slides show kidney tissue consisting of cortex and medulla. It also contains tubules in various shapes like proximal convoluted tubule and distal convoluted tubule. From this study, it is clear that the selected medicinal plant plays a prominent role against various diseases. The results of this study indicate that extracts of plant cassia auriculata linn does not show any nephrotoxicity and have good potentials for use in kidney damage.