Formulation and Evaluation of Fexofenadine HCL Rapid Dispersible Tablets by Using Direct Compression Method

Abstract

The research is going on to improve the solubility for low soluble drugs. The model candidate was to select to improve the solubility of Fexofenadine HCl and then to design rapid dispersible tablets. It is a competitive and highly selective β1 receptor antagonist with mild vasodilating properties, possibly due to an interaction with the L-arginine/nitric oxide pathway. Nine formulations of Fexofenadine HCl 100 mg were formulated by direct compression technique using different hydrophilic polymer grades such as cross povidone, sodium starch glycolate and cross carmellose sodium were used as polymers in different concentrations and other ingredients are Micro crystalline cellulose (MCC), Mannitol, and Talc and Magnesium stearate before the formulation the granules are evaluated by pre-compression studies. The obtained tablets were evaluated with different post-compression parameters like hardness, friability, thickness, weight variation, in- vitro disintegration studies and In-vitro dissolution studies. The formulation F3 was selected as an optimized formulation because it gives best results in terms of In - vitro drug release in a rapid release manner and best fitted to rapid order model with r value of 0.999.