Formulation and Evaluation of Dolutegravir Sodium Controlled Release Tablets

Authors

  • CH. Sathya Surya Prasad Associate Professor, Department of Pharmaceutics, Avanthi Institute of Pharmaceutical Sciences, Bhogapuram, India
  • Boddu Narayana Rao Student, Department of Pharmaceutics, Avanthi Institute of Pharmaceutical Sciences, Bhogapuram, India

Keywords:

Dolutegravir (DTG), HPMC K15M, Carbopol 971G, micro crystalline cellulose (MCC), controlled release tablets

Abstract

The present of this research work to develop Dolutegravir sodium 200 mg controlled release tablets. This is a second-generation HIV drug and it is comes under anti-retroviral category. In this work six formulations are selected for design Dolutegravir sodium controlled release formulations by using direct compression method and then the formulations are prepared by using different concentrations hydrophobic polymer and different ingredients are used as fillers to develop the formula. The granules and tablets are evaluated by pre-compression, post-compression and In-vitro dissolution studies. Based on the dissolution studies F6 was selected as an optimized formula because of it gives best results in controlled by drug release manner and best fitted to order of kinetics.

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Published

02-07-2021

Issue

Vol. 2 No. 6 (2021)

Section

Articles

License

Copyright (c) 2021 CH. Sathya Surya Prasad, Boddu Narayana Rao

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
C. S. Surya Prasad and B. Narayana Rao, “Formulation and Evaluation of Dolutegravir Sodium Controlled Release Tablets”, IJRAMT, vol. 2, no. 6, pp. 245–251, Jul. 2021, Accessed: Dec. 22, 2024. [Online]. Available: https://journals.ijramt.com/index.php/ijramt/article/view/926