Formulation and Evaluation of Meloxicam Fast Dissolving Tablets by Using Direct Compression Method

Abstract

The purpose of this research was to develop meloxicam fast dissolving tablets. This drug is an oxicam derivative and a NSAID with anti-inflammatory, antipyretic and analgesic activities. It is usual nonselective NSAID. This is preferentially inhibited the action of cyclooxygenase II (COX-II), and the follow-on in a decrease transfer of arachidonic acid into prostaglandin precursor. Based on the result the prostaglandin synthesis is accountable for the therapeutic effects of the drug. Six formulations of meloxicam 200 mg were formulated by direct compression technique using different hydrophilic polymer grades such as PEG-400, PVP k100 as a polymers and different ingredients in different concentrations such as Micro crystalline cellulose, sodium starch glycolate, and Mannitol, Talc and Magnesium stearate. The earlier the all formulation of the granules is evaluated by pre-compression studies and after compression of tablets was evaluated with different post-compression parameters, In- vitro disintegration studies and In-vitro dissolution studies. The formulation F3 was chosen as an optimized formulation as it gives best results in terms of In - vitro drug release in a fast discharge manner. Based results the F3 formulation as followed by first order of kinetics with R value is 0.999.